The play-off comes off in March.
The Black Stars are in search of a fourth qualification for FIFA World Cup since making their debut in 2006 in Germany and must overcome their archrivals for a place at the global showpiece in Qatar.
Ghana were in the same group as Ethiopia, South Africa and Zimbabwe in group G during the qualifiers and topped the group to make it to the playoffs.
Former Liverpool forward El-Hadji Diouf was one of the people performing the draw, and he happened to ensure that one of Liverpool’s current star strikers Sadio Mane or Mohamed Salah will be guaranteed a place at the tournament after Senegal were paired against Egypt, reports the BBC.
And the hosts of the current ongoing Afcon competition, Cameroon, are drawn against the current holders – albeit already eliminated from this year’s tournament – Algeria.
DR Congo, who last qualified for the World Cup in 1974 when the country was known as Zaire, have a tough challenge if they are to make it to a second tournament, as they face Morocco.
Meanwhile Morocco’s neighbours Tunisia will get through if they overcome the only team in the draw to have never been at a World Cup in any form, Mali.